The Science Behind Antidepressant Companion

Designed based on clinical evidence and backed by research, Antidepressant Companion is the #1 most effective product on the market that is formulated specifically to target replenishing nutrients needed to build adequate amounts of neurotransmitters, as well as to replace the specific depletion of nutrients caused by the medications. Equally important, Antidepressant Companion provides supportive therapies that address the cause of the side effects and gives your body the ability to function at peak performance, while also targeting the underlying cause of depression itself.

Antidepressant Companion & Neurotransmitters

  • Neurotransmitters are chemicals that carry information from one neuron to another in the brain allowing it to function optimally and maintain a calm, happy and stable mood..
  • Antidepressant medications alter neurotransmitters in your brain.
  • Antidepressant medications deplete certain key nutrients needed for mood, metabolism and sleep which is responsible for many side effects.
  • Antidepressant medications also impact the production and metabolism of other hormones and neurotransmitters in the body causing body wide side effects.

Neurotransmitters are chemicals that carry information from one neuron to another in the brain. Neurotransmitters and hormones interplay with each other in balancing your brain and body. When they are in balance, they help to keep your mood calm, happy and stable. When they are out of balance you are more susceptible to depression, anxiety, and other mental health issues.

There are five key neurotransmitters involved in the regulation of mood. These include but are not limited to: Serotonin, Dopamine, Norepinephrine, Epinephrine, and Gamma-aminobutyric acid (GABA).

Antidepressant medications work by altering these neurotransmitters. There are many different forms of antidepressants and each target the brain slightly differently.

Selective Serotonin Reuptake Inhibitors (SSRIs) such as Prozac, Celexa, Lexapro and Zoloft work by preventing the nerve cells in your brain from reabsorbing serotonin. It has been shown clinically that having higher levels of serotonin available to the brain results in increased feelings of satisfaction and happiness.

Another example includes the category of antidepressants called: Serotonin Norepinephrine Reuptake Inhibitors (SNRIs), such as Effexor, Cymbalta and Pristiq. SNRI medications increase both serotonin and norepinephrine in the brain by blocking its reabsorption which allows for more communication of serotonin and epinephrine between the cells in the brain–which, just like SSRIs, results in increased feelings of happiness.

Because of the delicate interplay of neurotransmitters and hormones in the body, SSRI and SNRI medications cause changes in other neurotransmitters and hormones by changing the amount of the neurotransmitter they are targeting. These differ for the different drug categories because of the difference in the targeting of specific neurotransmitters. One hormone alteration that is common to both SSRIs and SNRIs is melatonin. This is due to the fact that aAntidepressant medications increase the amount of nutrients (building blocks) the body needs to fuel neurotransmitter production to try and maintain the ideal balance. By taking an antidepressant, your body essentially burns through all of its nutrients that help produce neurotransmitters faster.

This can negatively impact the body’s production and use of other hormones and neurotransmitters, leading to a high potential for hormonal imbalances.  Many of these hormonal imbalances and changes in nutrient needs are responsible for the unpleasant side effects of the medication, namely insomnia, sexual dysfunction, and weight gain.

Nutrient Depletion and Neurotransmitter

In his article How SSRI’s Deplete Neurotransmitter Levels, Dr. Kaslow addresses the mechanism of action of SSRIs and how it can actually work against us. The leading theory is that as the number of neurotransmitters in the synaptic cleft increase, the Monoamine Oxidase (MAO) system is stimulated to break down those excess neurotransmitters. The body therefore has to produce more neurotransmitters which then again triggers the MAO system to break them down. This results in continued depletion of the precursor building blocks over time thus requiring higher and higher doses of medications with decreasing effectiveness. (Reference: Kaslow, J. MD. (2015) How SSRI’S Deplete Neurotransmitter Levels.)

Antidepressant Companion and Side Effects

Antidepressant Companion also provides supportive therapies that address the cause of the side effects, while also targeting the underlying cause of depression itself. These medicinal herbs have been selected based off of their demonstrated value through years of clinical experience working with real people dealing with the challenges of daily life. They have also been studied in laboratory settings and hold up to double blind placebo controlled trials. Each herb has its unique purpose, and all work synergistically to improve effectiveness. For more information on these herbs and all of the ingredients of Antidepressant Companion click here.


In summary Antidepressant Companion will accomplish three key objectives:  

  1. Replace nutrients and hormones that are depleted by antidepressants.
  2. Reinforce the body’s ability to produce chemicals associated with improved mood by providing the building blocks in therapeutic doses.
  3. Reduce the most common and troublesome side effects such as weight gain, insomnia, and sexual dysfunction with powerful herbs and nutrients formulated to work with your medication.

“I have been depressed for over 40 years. None of my doctors ever told me that I had a genetic mutation that made me unable to make serotonin properly. Now that I am on the appropriate vitamin regimen, I am happy for the first time in my life. I have even been able to get off my medications and have better energy, sex drive, and I have lost weight.”



Click here to read about the research backing the NMHS Antidepressant Companion Formulation.

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