Melatonin will help regulate your sleep so when you wake up, you’re ready to conquer your day!

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What can Melatonin do for me?

By Shannon Bennett and Dr. Nicole Cain ND, MA

Are you on an antidepressant but have trouble falling asleep or staying asleep? Do you feel sleepy, suffer from brain fog, poor memory, and lethargy throughout the day?

If so, you might benefit from the safe, quick acting, and powerful antioxidant called melatonin.

Melatonin is a hormone secreted by a gland in your brain called the pineal gland when it is dark outside. Melatonin release is suppressed when it is light outside or when we are exposed to blue lights– television and phone screens for example.

Melatonin regulates your sleep wake cycle (circadian rhythm), and impacts your mood, and regulates many metabolic functions.

Melatonin is one of the 3 main nutrients depleted by the use of anti-depressants, like Prozac2,3, which is one of the main reasons you may be experiencing insomnia while taking your antidepressant.  

In addition to regulating sleep and correcting jet lag, few people know of melatonin’s use as a powerful antioxidant in alternative treatments for cancer, aging and mental health.

Antioxidants are molecules that bind up all of the harmful free radicals circulating in our bodies, thus decreasing the damage caused by oxidation in our cells. To explain oxidation in a little more detail: Oxidation is the reaction occurring when your half-eaten apple turns brown, when a car rusts and oxidation is the cause or consequence in some diseases. Other common antioxidants include vitamins A, C, and E, n-acetylcysteine and selenium.

Melatonin helps your body regulate hormones, controls irritable bowel, and combats brain fog, difficulty focusing and poor concentration.

Interestingly we see a link between melatonin and the neurotransmitter dopamine. In making dopamine, your brain needs adequate amounts of melatonin. Therefore if you suffer from ADD/ ADHD or any other issues with focus and attention, you might be deficient in melatonin.  

Melatonin is particularly important if you’re a busy, over-worked, over-stressed individual. At this point, you’re probably thinking this supplement should be added to your daily regimen. If you’re one of the 11% of Americans on antidepressants1, you’ll be glad to know that this vital hormone is not going to cause any interactions with your bottled sunshine. In fact, it may benefit you even more than the antidepressant alone.

As mentioned above, Melatonin is also a major building block for the production of neurotransmitters such as serotonin, dopamine, norepinephrine and epinephrine. These neurotransmitters happen to be primarily involved in mood regulation, response to stressors and our overall ability to adapt easily and thrive in life.

How good does that sound? To not just survive in life but to THRIVE?

The regulation of these neurotransmitters is intricately involved in the treatment of depression, anxiety and other mental health-related disorders4. Serotonin is the target for SSRIs, impacting the amount available for your body’s use.

To Summarize:

  • Your antidepressant may be depleting your body of melatonin.
  • Melatonin dysregulation leads to insomnia
  • Melatonin is a safe, effective, natural and powerful alternative to medications in helping you sleep again.
  • As an extremely powerful antioxidant, melatonin heals the brain!
  • Melatonin prevents neurdegenerative disorders, for example alzheimers.
  • Melatonin is needed to make dopamine which is the first line treatment in ADHD/ ADD

At Natural Mental Health Supplements we are passionate about creating solutions to the mental health crisis that is occurring in the United States.

By helping one person at a time, one nutrient at a time, we hope to change the world. Step by step. By helping you get on the road to a new life, we know that you will positively impact those around you, and then those around you will impact the world around them.

Our mission is to EMPOWER you in taking back your health.

Antidepressant Companion was specifically formulated to compliment antidepressants as they are working in your body. It does this by providing therapeutic dosages of quality Melatonin to counteract and decrease the negative effects of this known depletion.

Speak with your healthcare provider today about using Antidepressant Companion on your journey to a healthy, and well-rested life!  

References:

  1. http://www.businessinsider.com/countries-largest-antidepressant-drug-users-2016-2
  2. http://pennstatehershey.adam.com/content.aspx?productId=107&pid=33&gid=000712
  3. Br J Psychiatry. 1995 Feb;166(2):196-8. Effect of fluoxetine on melatonin in patients with seasonal affective disorder and matched controls. Childs PA1, Rodin I, Martin NJ, Allen NH, Plaskett L, Smythe PJ, Thompson C.
  4. Psychoneuroendocrinology. 1995;20(7):763-70. Plasma melatonin and cortisol circadian patterns in patients with obsessive-compulsive disorder before and after fluoxetine treatment. Monteleone P1, Catapano F, Tortorella A, Di Martino S, Maj M.

5 Reasons Your SSRI Gives You Side Effects

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It’s an age old tale: You are feeling depressed. You go to your doctor and are prescribed an antidepressant. For a while things get a little better, but after a time, the depression starts to creep back. You go back to your doctor and your dosage is increased. This helps push back the feelings of sadness but now you are having difficulty sleeping and are gaining weight. Your doctor explains that these are common side effects of this medication and he switches you to a different kind of antidepressant. It’s the same story: At first things seem to go alright but the depression always comes back, and this time the side effects include: anxiety, struggling to focus and you feel detached emotionally. Another medication is added to your regimen to help with focus, and yet another is added to curb the feelings of panic. Every day now you go to your pill dispenser and swallow back a handful of medications. But you don’t feel happy and you don’t feel like yourself. You feel lost.

Does this sound familiar? If so, know that you are not alone.

There are five main reasons your SSRI may be causing you side effects:

1) Oxidative damage

Oxidative damage is a term you have probably heard in the news. It refers to damage to the cells and tissue caused by oxidation. Oxidation is a normal process where an oxygen molecule removes electrons from a another molecule or atom. This, however, causes damage to the cell, and can be problematic when there is too much of this process occurring.

We see that more oxidative stress is associated with a higher risk of becoming depressed and staying depressed (1)(2) and antidepressants can cause a worsening of depression by causing oxidative stress in the brain. For example, The Journal of Basic Clinical Physiological Pharmacology found that sertraline (Zoloft), which is an selective serotonin reuptake inhibitor (SSRI) antidepressant, caused oxidative stress in the brain of test subjects (3).

Our body is built to counteract oxidative damage through the production of enzymes that can neutralize the oxygen. Examples of enzymes include vitamins E and A. Consuming foods that are high in antioxidants, which are nutrients that inhibit oxidation, can provide your body with powerful tools in healing all of the tissues and cells in your brain and body. There are many additional powerful vitamins, minerals, and herbs that act as antioxidants to counteract the side effects of your antidepressant, heal the brain and improve your mood.

2) Increased demand for B vitamins

Antidepressants work by increasing the amount of available mood-supporting chemicals, called neurotransmitters, in the brain. Selective serotonin reuptake inhibitors (SSRI) antidepressants, for example, stop your brain from reuptaking  serotonin so that more of it remains available for use. In order to produce more chemicals like serotonin, dopamine, epinephrine and norepinephrine, the brain requires more building blocks. Particularly important building blocks include your B vitamins. For those taking antidepressants, an ongoing supply of the B vitamins must be available as cofactors to help manufacture the needed neurotransmitters (4)(5).

What often happens, is that in the beginning, your body has enough vitamins and minerals to produce adequate amounts of neurotransmitters. However, if the supply of building blocks does not increase in tandem with the demand, you will start to develop side effects from your antidepressant.. Symptoms will vary based on which nutrient is depleted, but most noteworthy is that it will appear that your antidepressant is not working properly any more. Also side effects will become more pronounced., You may be instructed to increase your dose of the drug, add on a new medication, or change to something different, when perhaps all you needed was a little nutritional support.

3) Blocking ATP

Adenosine triphosphate (ATP) functions in your body like the battery in a car. It is produced by every cell in your brain and body, and is used as  energy so that your cells can function. We get the building blocks to make ATP from our food and without enough ATP we will cease to function and live.

Antidepressants impair your cells ability to make ATP resulting in your cells not having  enough energy to carry out their normal functions. This causes myriad symptoms including but not limited to: depression, fatigue, muscle weakness, and diminished brain power (6).

There are many nutrients that can help you increase the amount of ATP in your cells. These may include: Coenzyme Q10, magnesium, vitamin B1, vitamin B2, and vitamin B3. It is important, however, to ensure you are taking the proper dosages and forms of these nutrients because some varieties of these nutrients are not well absorbed or utilized by the body.

4) Blocking CoQ10

CoQ10 (ubiquinone) is a coenzyme that is found in every single cell of your body. Healthy cells produce CoQ10 and it is used to protect the body and brain from oxidative damage and harmful substances. CoQ10 can be found in many types of foods like beef, sardines, and peanuts. You can also get it in a dietary supplement.

If you do not have enough CoQ10, you will be at a higher risk of depression, certain types of cancer, and more. Signs of low CoQ10 include: Depression, anxiety, high blood pressure, chest pain, memory loss, asthma, chronic fatigue, gum disease, migraines, weakness, nerve pain, and more.

Antidepressants can cause side effects and increase your risk of depression by actually depleting your body of CoQ10. In fact, low CoQ10 has been shown to play a role in “treatment resistant depression” which is depression that does not seem to improve despite treatment (7)(8)(9). Supplementing with the proper form and dosage of CoQ10 has been shown to be a powerful, natural, antidepressant and can help not only curb side effects of your antidepressants, but also help you feel less depressed to begin with.

5) Depletion of Melatonin

Melatonin is a molecule that is released by a gland in your brain, called the pineal gland. Melatonin is involved in regulating your sleep-wake cycle, called the circadian rhythm, and is also very closely linked to mood stability. When the sun goes down, there is less of a particular type of wavelength of light called “blue light,” and as a result the brain produces more melatonin to tell your brain it is time to go to sleep. Melatonin not only helps you get a good night’s rest but it is also a powerful antioxidant, protects against weight gain, heart disease and even migraine headaches and Alzheimer’s disease.

Research has shown that certain medications, including antidepressant medications like fluoxetine (Prozac), deplete the body of melatonin. This  may be in part why patients experience sleeping difficulties while taking these medications (10).

If you are taking an antidepressant, and are having difficulty sleeping it is possible that you may be having difficulties due to decreased melatonin stores. Before adding more medications to your regimen, like sleep aids, consider asking your doctor about if melatonin might be right for you.

Replace Nutrients for Better Health

If you are taking an antidepressant medication and are experiencing side effects, it is possible that proper supplementation may help to relieve your symptoms. There is an increasing body of evidence showing how vitamins, minerals, and certain herbs can help your brain and body heal. Know that you are not alone in your journey towards health, and that there are science-based solutions to helping you feel like yourself again. You can feel better, the journey starts with healing the body so that you can heal your mind. Get started today!

By: Dr. Nicole Cain, ND MA

References:
1)   Oxidative Stress is Related to Depression: “antioxidant levels are lower, and the serum free radical and oxidative damage product levels are higher than controls in depressed patients”: PLoS One. 2015 Oct 7;10(10):e0138904. doi: 10.1371/journal.pone.0138904.
2)   Novel Therapeutic Targets in Depression and Anxiety: Antioxidants as a Candidate Treatment Ying Xu,1,Δ Chuang Wang,2,Δ Jonathan J Klabnik,3 and James M O’Donnell1,* Curr Neuropharmacol. 2014 Mar; 12(2): 108–119. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964743/
3)   Antidepressants can cause oxidative stress in the brain: “Sertraline decreased catalase and PON1 activity which might expose the brain to further oxidative insults” J Basic Clin Physiol Pharmacol. 2013;24(2):115-23. doi: 10.1515/jbcpp-2012-0022. Brain and liver oxidative stress after sertraline and haloperidol treatment in mice. Abdel-Salam OM1, Youness ER, Khadrawy YA, Sleem AA.
4)   Bottiglieri T. “Folate, vitamin B12 and neuropsychiatric disorders.” Nutrition Review Dec 1996; 54(12): 382-390. Retrieved from http://nutritionreview.org/2013/04/practical-guide-avoiding-drug-induced-nutrient-depletion/
5)   Bottiglieri T, M Laundy, R Crellin, et al. “Homocysteine, folate, methylation, and monoamine metabolism in depression.” Journal of Neurology, Neurosurgery & Psychiatry Mar 2001; 70(3): 419. Retrieved from http://nutritionreview.org/2013/04/practical-guide-avoiding-drug-induced-nutrient-depletion/
6)   Oxford Journals. Toxicological Sciences. Mitochondrial Dysfunction Induced by Sertraline, an Antidepressant Agent. Yan Li*, Letha Couch†, Masahiro Higuchi‡, Jia-Long Fang† and Lei Guo†,1.
7)   Drugs that Deplete: Coenzyme Q102011). PennState Hershey. Milton S. Hersehey Medical Center. Retrieved on 4/1/15 from  http://pennstatehershey.adam.com/content.aspx?productId=107&pid=33&gid=000706
8)   Low COQ10 plays a role in the cause of depression, especially depression associated with treatment resistant depression, and chronic fatigue syndrome: “The results show that lower CoQ10 plays a role in the pathophysiology of depression and in particular in TRD and CFS accompanying depression” Neuro Endocrinol Lett. 2009;30(4):462-9. Lower plasma Coenzyme Q10 in depression: a marker for treatment resistance and chronic fatigue in depression and a risk factor to cardiovascular disorder in that illness. Maes M1, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E. http://www.ncbi.nlm.nih.gov/pubmed/20010493
9)   Neuro Endocrinol Lett. 2009;30(4):462-9. Lower plasma Coenzyme Q10 in depression: a marker for treatment resistance and chronic fatigue in depression and a risk factor to cardiovascular disorder in that illness. Maes M1, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E. http://www.ncbi.nlm.nih.gov/pubmed/20010493
10)  Penn State Hershey Milton S. Hershey Medical Center. Drugs that Deplete: Melatonin. Retrieved from:  http://pennstatehershey.adam.com/content.aspx?productId=107&pid=33&gid=000712

3 Ways to Reverse the Libido Squashing Effects of your Antidepressant Medications

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Having a satisfying intimate relationship with your partner is important in the lives of most adults, however, low libido (meaning lack of interest or decreased function) is a potential side effect of all antidepressant medications (1). The good news is that is possible to keep things happy in the bedroom and the rest of your life while taking your antidepressant.

reversethelibidosquashingeffectsofyourantidepressantTWO

Three ways Antidepressant Companion reverses the low libido blues:

1) Libido Boost

There are three key players to the Antidepressant Companion formulation to help boost your libido.

L-Tyrosine: L-tyrosine is and amino acid used by your brain to make chemicals called neurotransmitters. Some of them made from tyrosine include epinephrine, norepinephrine, and dopamine. These neurotransmitters are key players in your feelings of satisfaction, libido, and energy. Studies have shown that supplementation with L-tyrosine can work quickly to help with erectile dysfunction, achieving orgasm, and increasing interest.

Saffron: Saffron is a delicious spice that has been shown to be as effective as Prozac in treating depression (2), but that’s not all!. In addition to being a powerful antidepressant, Saffron blocks the libido squashing side effects of your antidepressant, and it can also help improve erectile function, arousal, lubrication and interest (3)(4)(5).

L-Citrulline: L-Citrulline is another amino acid that has been used to effectively treat low libido. It is a powerful antioxidant and can treat mild to moderate erectile dysfunction (6). It also helps major depression by increasing production of the chemical nitric oxide (NO), which is associated with blood circulation, energy, libido and more (7)(8).

2) Tapering Down

Often times the side effects of antidepressants are tied to their dosages. Clinical studies have shown that lowering the dose of your antidepressant may enable you to achieve the same mood-lifting benefits, while not experiencing the effect on your libido. Antidepressants work by increasing the amounts of mood stabilizing chemicals in your brain, primarily serotonin, and in some cases norepinephrine. Antidepressant Companion contains building blocks that helps your brain more effectively and easily make these chemicals so that you do not need higher and higher doses in order to maintain stability. Instead, the health-promoting ingredients in Antidepressant Companion will get to the root of your symptoms and help you start to feel better again.

3) Mood support

It is well known that depression impacts your ability to connect with others, your self confidence, your ability to experience pleasure, and therefore your libido. While your antidepressant may be helpful in lifting some of the weight of depression, you may still experience symptoms sadness and anxiety.

Antidepressant companion has nutrients that help boost mood and energy. It decreases inflammation in the brain and body, which has been shown to help improve the symptoms of depression. It also provides your brain with an abundance of antioxidant support, and gives your brain the needed building blocks for making mood-boosting neurotransmitters. With a powerful proprietary blend of herbal medicines, Antidepressant Companion targets and removes oxidative damage, improves energy, and can help lift depression and anxiety.

By Dr. Nicole Cain, MA ND

References:
1) Higgins, A. Nash, M. & Lynch, A.M. Antidepressant-associated sexual dysfunction: impact, effects, and treatment. Dove Press Journal: Drug, Healthcare and Patient Safety. 8 September 2010. Retrieved from http://edepositireland.ie/bitstream/handle/2262/68355/dhps-2-141.pdf?sequence=1&isAllowed=y
2) Lopresti AL, Drummond PD. Saffron (Crocus sativus) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action. Human Psychopharmacology. 2014 Sept. 22. http://onlinelibrary.wiley.com/doi/10.1002/hup.2434/abstract
3) J Integr Med. 2013 Nov;11(6):377-83. doi: 10.3736/jintegrmed2013056. Saffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trials. Hausenblas HA1, Saha D, Dubyak PJ, Anton SD.
4) Modabbernia A, Sohrabi H, Nasehi AA, et al. Effect of saffron on fluoxetine-induced sexual impairment in men: randomized double-blind placebo-controlled trial. Psychopharmacology (Berl). 2012;223(4):381-8.
5) Kashani L, Raisi F, Saroukhani S, et al. Saffron for treatment of fluoxetine-induced sexual dysfunction in women: randomized double-blind placebo-controlled study. Hum Psychopharmacol. 2013 Jan;28(1):54-60.
6) Urology. 2011 Jan;77(1):119-22. doi: 10.1016/j.urology.2010.08.028. Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction. Cormio L1, De Siati M, Lorusso F, Selvaggio O, Mirabella L, Sanguedolce F, Carrieri G.
7) Nitric Oxide and Neopterin in Bipolar  Affective Disorder. R. Hoekstra   W.M.A. Verhoeven a D. Fekkes. Neuropsychobiology 2006;54:75–81.
8) Decreased Platelet Nitric Oxide Synthase Activity and  Plasma Nitric Oxide Metabolites in Major Depressive Disorder.  Wendy E. Chrapko, Paul Jurasz, Marek W. Radomski, Nathalie Lara, Stephen L. Archer, and  Jean-Michel Le Melle ́do. BIOL PSYCHIATRY 2004;56:129–134

 

Antidepressant Companion

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Antidepressant Companion

Finally there is a nutritional supplement that can reduce or remove the side effects of common antidepressants. Antidepressant Companion is designed by a doctor using cutting edge medical research to address the unique nutrition needs of those who take antidepressants. Antidepressant Companion utilizes over 20 different physician grade ingredients for the primary goal of reducing insomnia, weight gain, and sexual side effects common with SSRI, SNRI, and other antidepressant medications.  Additionally the proprietary blend of herbs and amino acids included in Antidepressant companion will improve your overall response to your prescribed antidepressant.

Antidepressant Companion accomplishes it’s goal by providing the raw materials your body needs through the 3 R’s:

  • It REPLACES nutrients and hormones that are depleted by antidepressants.
  • It REINFORCES the body’s ability to produce chemicals associated with improved mood by providing the building blocks in therapeutic doses.
  • It REDUCES the most common and troublesome side effects such as weight gain, insomnia, and sexual dysfunction with powerful herbs and nutrients formulated to work with your medication.

Antidepressant Companion was developed by a doctor for Natural Mental Health Supplements.

Click here to buy Antidepressant Companion NOW!

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