Co-Q 10 is the powerful boost you’ve been looking for

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Learn what Co-Q 10 can do for you.

By Shannon Bennett and Dr. Nicole Cain ND, MA

With health care costs on the rise and depression becoming more and more common, we find ourselves looking for alternative treatments for depression. A powerful powerhouse nutrient that should not be ignored is: Coenzyme Q10 (COQ10, ubiquinone, ubiquinol).

COQ10 (ubiquinone and ubiquinol) is like the battery that goes in your car. It is used by every single cell in your body to provide energy. Energy helps your cells to work, it is needed to make hormones, neurotransmitters, it is needed for your neurons to send information. In short: COQ10 is essential for every single cell in your body.

But what does this have to do with your mental health?

At the basic level, Ubiquinone is vital in the energy production powerhouse, the mitochondria. Adequate levels allow for the body’s biochemical processes to be efficiently energized.

This is why early signs of deficiency are associated with lowered energy, brain fog and muscle weakness. Do these symptoms sound familiar?

They are some of the most common symptoms in depression.

Without adequate amounts of COQ10, people commonly suffer from depression– especially depression associated with chronic fatigue syndrome and treatment resistant depression4. Ubiquinone plays a particularly vital role in heart health as well and research has revealed a particularly intimate link between one’s heart health and their emotional wellbeing. Late signs that your levels may be low include chest pain, high blood pressure, rapid aging and Alzheimer’s disease3. In fact, because of this, COQ10 is very commonly recommended for patients suffering from heart disease. COQ10 can not only provide the body with the energy it needs for proper heart function but it serves preventive treatment for return of, or worsening of symptoms.

COQ10 deficiencies are becoming increasingly common. Unfortunately, COQ10 is one of the 3 main nutrients depleted while taking pharmaceuticals, such as tricyclic antidepressants1,2. This is why people often develop side effects and often worsening of their depression and anxiety after long term antidepressant use. The conventional medical model emphasizes adding additional medications or increasing dosages but this does not get to the root of the problem.

It’s only making it worse.

In the Philosophies of Natural Therapeutics, author, Dr. Henry Lindlhar acknowledges the advantages of preventing disease, rather than waiting for the development of disease and seeking to cure it6. He also provides profound insights into how to treat disease by addressing the root cause.

So, in respect to Dr. Lindlhar’s suggestion, supplementing with nutrients known to be involved in the development of depression may be beneficial while under pharmaceutical treatment. By targeting the root cause of why you are feeling worse on your antidepressant we can help reduce and often eliminate side effects, but we can also often help relieve the depression so that you may be able to taper down and often off of your medications. Note: Medications should always be adjusted under the supervision of your prescribing physician. It can be very harmful and dangerous to make medication adjustments without expert supervision.

Another benefit of Ubiquinone (a specific form of COQ10) is that it is one of the antioxidants that is able to cross the blood brain barrier7. This barrier is what separates the blood circulating in your body from the fluid in your central nervous system. This means that ubiquinol (a form of COQ10) is able to go straight into your brain where it can directly target your mind and mood. If you recall from the previous post regarding the powerful antioxidant melatonin, you know that antioxidants play a role in the development of neurodegenerative diseases. COQ10 is a powerful antioxidant and as we age Ubiquinone levels decrease, further increasing the risk of depletion– especially when paired with antidepressant use.

With Ubiquinone’s ability to reach the central nervous system, it is one of the most influential nutrients available for prevention of neurodegenerative changes in the brain.

At Natural Mental Health Supplements we understand the importance in giving the body what it needs to support optimal health. That is why we have specifically formulated Antidepressant Companion to be safely and effectively used in conjunction with pharmaceuticals, as a means to prevent the loss of the nutrients that impact your mental health.

Speak with your healthcare provider today about using Antidepressant Companion on your journey to a healthy, happy life!


1) Drugs that Deplete: Coenzyme Q10. University of Maryland Medical Center Medical Reference Guide. Complementary and Alternative medicine Guide.

2) Drugs that Deplete: Coenzyme Q102011). PennState Hershey. Milton S. Hersehey Medical Center. Retrieved on 4/1/15 from

3) Signs of low COQ10: heart disease, high blood pressure, chest pain, macular degeneration, early and rapid aging, chronic fatigue, and cognitive problems like depression, brain fog and alzheimers disease. Mayo Clinic. Drugs and Supplements: Coenzyme Q10.

4) Low COQ10 plays a role in the cause of depression, especially depression associated with treatment resistant depression, and chronic fatigue syndrome: “The results show that lower CoQ10 plays a role in the pathophysiology of depression and in particular in TRD and CFS accompanying depression” Neuro Endocrinol Lett. 2009;30(4):462-9. Lower plasma Coenzyme Q10 in depression: a marker for treatment resistance and chronic fatigue in depression and a risk factor to cardiovascular disorder in that illness. Maes M1, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E.

5) Pharmacol Biochem Behav. 2013 Mar;104:105-12. doi: 10.1016/j.pbb.2012.12.027. Epub 2013 Jan 11. Coenzyme Q10 displays antidepressant-like activity with reduction of hippocampal oxidative/nitrosative DNA damage in chronically stressed rats. Aboul-Fotouh S1.

6) Nature Cure; Philosophy and Practice Based on the Unity of Disease and Cure. Nature Cure Publishing. 1914. reprint General Books LLC, 2009, ISBN 978-1-150-08374-7

7) Yossi Gilgun-Sherki, Eldad Melamed, Daniel Offen (2000). Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier. Neuropharmacology 40 (2001) 959–975. Journal of Neuro Pharmacology 2000-2001. Retrieved from:

5 Reasons Your SSRI Gives You Side Effects

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It’s an age old tale: You are feeling depressed. You go to your doctor and are prescribed an antidepressant. For a while things get a little better, but after a time, the depression starts to creep back. You go back to your doctor and your dosage is increased. This helps push back the feelings of sadness but now you are having difficulty sleeping and are gaining weight. Your doctor explains that these are common side effects of this medication and he switches you to a different kind of antidepressant. It’s the same story: At first things seem to go alright but the depression always comes back, and this time the side effects include: anxiety, struggling to focus and you feel detached emotionally. Another medication is added to your regimen to help with focus, and yet another is added to curb the feelings of panic. Every day now you go to your pill dispenser and swallow back a handful of medications. But you don’t feel happy and you don’t feel like yourself. You feel lost.

Does this sound familiar? If so, know that you are not alone.

There are five main reasons your SSRI may be causing you side effects:

1) Oxidative damage

Oxidative damage is a term you have probably heard in the news. It refers to damage to the cells and tissue caused by oxidation. Oxidation is a normal process where an oxygen molecule removes electrons from a another molecule or atom. This, however, causes damage to the cell, and can be problematic when there is too much of this process occurring.

We see that more oxidative stress is associated with a higher risk of becoming depressed and staying depressed (1)(2) and antidepressants can cause a worsening of depression by causing oxidative stress in the brain. For example, The Journal of Basic Clinical Physiological Pharmacology found that sertraline (Zoloft), which is an selective serotonin reuptake inhibitor (SSRI) antidepressant, caused oxidative stress in the brain of test subjects (3).

Our body is built to counteract oxidative damage through the production of enzymes that can neutralize the oxygen. Examples of enzymes include vitamins E and A. Consuming foods that are high in antioxidants, which are nutrients that inhibit oxidation, can provide your body with powerful tools in healing all of the tissues and cells in your brain and body. There are many additional powerful vitamins, minerals, and herbs that act as antioxidants to counteract the side effects of your antidepressant, heal the brain and improve your mood.

2) Increased demand for B vitamins

Antidepressants work by increasing the amount of available mood-supporting chemicals, called neurotransmitters, in the brain. Selective serotonin reuptake inhibitors (SSRI) antidepressants, for example, stop your brain from reuptaking  serotonin so that more of it remains available for use. In order to produce more chemicals like serotonin, dopamine, epinephrine and norepinephrine, the brain requires more building blocks. Particularly important building blocks include your B vitamins. For those taking antidepressants, an ongoing supply of the B vitamins must be available as cofactors to help manufacture the needed neurotransmitters (4)(5).

What often happens, is that in the beginning, your body has enough vitamins and minerals to produce adequate amounts of neurotransmitters. However, if the supply of building blocks does not increase in tandem with the demand, you will start to develop side effects from your antidepressant.. Symptoms will vary based on which nutrient is depleted, but most noteworthy is that it will appear that your antidepressant is not working properly any more. Also side effects will become more pronounced., You may be instructed to increase your dose of the drug, add on a new medication, or change to something different, when perhaps all you needed was a little nutritional support.

3) Blocking ATP

Adenosine triphosphate (ATP) functions in your body like the battery in a car. It is produced by every cell in your brain and body, and is used as  energy so that your cells can function. We get the building blocks to make ATP from our food and without enough ATP we will cease to function and live.

Antidepressants impair your cells ability to make ATP resulting in your cells not having  enough energy to carry out their normal functions. This causes myriad symptoms including but not limited to: depression, fatigue, muscle weakness, and diminished brain power (6).

There are many nutrients that can help you increase the amount of ATP in your cells. These may include: Coenzyme Q10, magnesium, vitamin B1, vitamin B2, and vitamin B3. It is important, however, to ensure you are taking the proper dosages and forms of these nutrients because some varieties of these nutrients are not well absorbed or utilized by the body.

4) Blocking CoQ10

CoQ10 (ubiquinone) is a coenzyme that is found in every single cell of your body. Healthy cells produce CoQ10 and it is used to protect the body and brain from oxidative damage and harmful substances. CoQ10 can be found in many types of foods like beef, sardines, and peanuts. You can also get it in a dietary supplement.

If you do not have enough CoQ10, you will be at a higher risk of depression, certain types of cancer, and more. Signs of low CoQ10 include: Depression, anxiety, high blood pressure, chest pain, memory loss, asthma, chronic fatigue, gum disease, migraines, weakness, nerve pain, and more.

Antidepressants can cause side effects and increase your risk of depression by actually depleting your body of CoQ10. In fact, low CoQ10 has been shown to play a role in “treatment resistant depression” which is depression that does not seem to improve despite treatment (7)(8)(9). Supplementing with the proper form and dosage of CoQ10 has been shown to be a powerful, natural, antidepressant and can help not only curb side effects of your antidepressants, but also help you feel less depressed to begin with.

5) Depletion of Melatonin

Melatonin is a molecule that is released by a gland in your brain, called the pineal gland. Melatonin is involved in regulating your sleep-wake cycle, called the circadian rhythm, and is also very closely linked to mood stability. When the sun goes down, there is less of a particular type of wavelength of light called “blue light,” and as a result the brain produces more melatonin to tell your brain it is time to go to sleep. Melatonin not only helps you get a good night’s rest but it is also a powerful antioxidant, protects against weight gain, heart disease and even migraine headaches and Alzheimer’s disease.

Research has shown that certain medications, including antidepressant medications like fluoxetine (Prozac), deplete the body of melatonin. This  may be in part why patients experience sleeping difficulties while taking these medications (10).

If you are taking an antidepressant, and are having difficulty sleeping it is possible that you may be having difficulties due to decreased melatonin stores. Before adding more medications to your regimen, like sleep aids, consider asking your doctor about if melatonin might be right for you.

Replace Nutrients for Better Health

If you are taking an antidepressant medication and are experiencing side effects, it is possible that proper supplementation may help to relieve your symptoms. There is an increasing body of evidence showing how vitamins, minerals, and certain herbs can help your brain and body heal. Know that you are not alone in your journey towards health, and that there are science-based solutions to helping you feel like yourself again. You can feel better, the journey starts with healing the body so that you can heal your mind. Get started today!

By: Dr. Nicole Cain, ND MA

1)   Oxidative Stress is Related to Depression: “antioxidant levels are lower, and the serum free radical and oxidative damage product levels are higher than controls in depressed patients”: PLoS One. 2015 Oct 7;10(10):e0138904. doi: 10.1371/journal.pone.0138904.
2)   Novel Therapeutic Targets in Depression and Anxiety: Antioxidants as a Candidate Treatment Ying Xu,1,Δ Chuang Wang,2,Δ Jonathan J Klabnik,3 and James M O’Donnell1,* Curr Neuropharmacol. 2014 Mar; 12(2): 108–119.
3)   Antidepressants can cause oxidative stress in the brain: “Sertraline decreased catalase and PON1 activity which might expose the brain to further oxidative insults” J Basic Clin Physiol Pharmacol. 2013;24(2):115-23. doi: 10.1515/jbcpp-2012-0022. Brain and liver oxidative stress after sertraline and haloperidol treatment in mice. Abdel-Salam OM1, Youness ER, Khadrawy YA, Sleem AA.
4)   Bottiglieri T. “Folate, vitamin B12 and neuropsychiatric disorders.” Nutrition Review Dec 1996; 54(12): 382-390. Retrieved from
5)   Bottiglieri T, M Laundy, R Crellin, et al. “Homocysteine, folate, methylation, and monoamine metabolism in depression.” Journal of Neurology, Neurosurgery & Psychiatry Mar 2001; 70(3): 419. Retrieved from
6)   Oxford Journals. Toxicological Sciences. Mitochondrial Dysfunction Induced by Sertraline, an Antidepressant Agent. Yan Li*, Letha Couch†, Masahiro Higuchi‡, Jia-Long Fang† and Lei Guo†,1.
7)   Drugs that Deplete: Coenzyme Q102011). PennState Hershey. Milton S. Hersehey Medical Center. Retrieved on 4/1/15 from
8)   Low COQ10 plays a role in the cause of depression, especially depression associated with treatment resistant depression, and chronic fatigue syndrome: “The results show that lower CoQ10 plays a role in the pathophysiology of depression and in particular in TRD and CFS accompanying depression” Neuro Endocrinol Lett. 2009;30(4):462-9. Lower plasma Coenzyme Q10 in depression: a marker for treatment resistance and chronic fatigue in depression and a risk factor to cardiovascular disorder in that illness. Maes M1, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E.
9)   Neuro Endocrinol Lett. 2009;30(4):462-9. Lower plasma Coenzyme Q10 in depression: a marker for treatment resistance and chronic fatigue in depression and a risk factor to cardiovascular disorder in that illness. Maes M1, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E.
10)  Penn State Hershey Milton S. Hershey Medical Center. Drugs that Deplete: Melatonin. Retrieved from:

You are not Alone

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Believe it or not, you are not alone. You have struggled with depression, and have felt the most alone you have ever felt in your life, but you are actually in good company. With 25% of the American population struggling with some type of mental health condition, you actually have over 77 million people with you. They get how you feel, and so do we.

You are also not alone in feeling side effects from your medications. If you are lucky, you are among the two-thirds of people who take antidepressants and see improvement. However there is a trade off.  Over forty percent of people who get some relief from depression with their antidepressants end up experiencing side effects. The most common ones we hear from our patients include insomnia, low libido and weight gain. And there is evidence in the scientific literature to back up what you are feeling. (1). So you may have some relief of your depression (or complete relief), but now you have to deal with increased weight, difficulty sleeping, and low libido. Sometimes these side effects make people feel so frustrated that they feel it might even be better to deal with depression, so they stop their medications and suddenly get flooded with depression again. Sound familiar?

There is hope. You can feel better in you body and your mind. Millions have found relief in integrative approaches to mental health, whether it be through diet or with supplements. Our doctors have over a decade of experience in the study of nutrition and the brain and NMHS was created with the mission to help people finally find the relief they are looking for.

Antidepressant Companion was formulated specifically with you in mind. Packed full of nutrients that help get to the root of depression and anxiety, Antidepressant Companion contains specific vitamins, minerals, and herbs in their optimal dosages and forms. These ingredients will not only heal your brain, but it will also target the side effects of your medications. We have found that people who take Antidepressant Companion get better sleep, have more success in achieving their weight goals, and have a healthier sex life. Antidepressant Companion also increases the effectiveness of your antidepressant medication and may even help you to taper off.

There is hope. While you may feel alone and like you will never feel better, millions of people have experienced relief and so can you. Talk with your doctor about Antidepressant Companion today and get on the road to new life.

by Dr. Nicole Cain, ND MA 

Elisa Cascade,corresponding author Amir H. Kalali, MD, and Sidney H. Kennedy, MD, FRCPC. Real-World Data on SSRI Antidepressant Side Effects. Psychiatry (Edgmont). 2009 Feb; 6(2): 16–18. Retrieved from


Meet the Doctor Behind Natural Mental Health Supplements

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Meet the Doctor

Dr. Nicole Cain, ND MA founded Natural Mental Health Supplements because of her vision to bring natural solutions to her patients and thousands of others whom she observed surviving instead of thriving. Dr. Cain is an expert in natural and integrative treatments of psychiatric conditions, and is passionate about truly changing how mental healthcare is delivered in America

In the doctor’s words: “I formed natural mental health supplements after years in practice watching my patients take handfuls of pills every day. Some of their pills were prescription medications that they required in order to have a stable mood, and in some of the pills were a myriad of supplements that were given to them by their other healthcare practitioners. My patients came in and complained that they still had side effects, they were spending lots of money on their supplements (often times many of which were such low doses of the actual nutrient or the wrong form of the nutrient that it wasn’t actually offering them any clinical benefit), and they had trouble eating because their stomachs were full of all of pills they were taking. They were miserable and looking for an alternative. My mission in creating Natural Mental Health Supplements was to formulate supplements that were high quality, cost-efficient, and powerful. I worked to create a product that would enable my patients to take much less pills.

The solution to this was my first product called Antidepressant Companion. I began with Antidepressant Companion because the number one concern that I see clinically in practice is depression. In fact, the most common medication prescribed for mood stabilization is an antidepressant.

My passion is to help my patients feel better and there was no nutritional supplement on the market to help those taking SSRI Antidepressant drugs. There is an extraordinary amount of research discussing how nutrients impact the way that your brain and body function. I’ve spent years studying the pharmakinetics of vitamins, minerals, herbs and other nutrients as they relate to the brain and body. This in combination with my clinical experience lent to a powerful database of information and thus, Natural Mental Health Supplements was born.”

Dr. Cain specializes in the integrative treatment of bipolar disorder, depression, anxiety, postpartum depression and post traumatic stress disorder (PTSD). She received a Doctorate of Naturopathic Medicine from the Southwest College of Naturopathic Medicine (SCNM), where she also completed an accredited residency in internal medicine. She has a graduate degree from The Chicago School of Professional Psychology (CSOPP) with a M.A. in Clinical Psychology. She studied psychobiology and psychoneuroimmunology during undergraduate training at Luther College. Dr. Cain is a medical consultant for Orb Health, and has participated on the board of Arizona Naturopathic Medical Association (AZNMA), she has also been on the clinical and didactic faculty at Southwest College of Naturopathic Medicine. To read more about Dr. Cain click here.

To purchase Natural Mental Health Supplements’ first product Antidepressant Companion click here.

Antidepressant Companion

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Antidepressant Companion

Finally there is a nutritional supplement that can reduce or remove the side effects of common antidepressants. Antidepressant Companion is designed by a doctor using cutting edge medical research to address the unique nutrition needs of those who take antidepressants. Antidepressant Companion utilizes over 20 different physician grade ingredients for the primary goal of reducing insomnia, weight gain, and sexual side effects common with SSRI, SNRI, and other antidepressant medications.  Additionally the proprietary blend of herbs and amino acids included in Antidepressant companion will improve your overall response to your prescribed antidepressant.

Antidepressant Companion accomplishes it’s goal by providing the raw materials your body needs through the 3 R’s:

  • It REPLACES nutrients and hormones that are depleted by antidepressants.
  • It REINFORCES the body’s ability to produce chemicals associated with improved mood by providing the building blocks in therapeutic doses.
  • It REDUCES the most common and troublesome side effects such as weight gain, insomnia, and sexual dysfunction with powerful herbs and nutrients formulated to work with your medication.

Antidepressant Companion was developed by a doctor for Natural Mental Health Supplements.

Click here to buy Antidepressant Companion NOW!

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